Review of Cabergoline

Review of Cabergoline

Cabergoline belongs to the class of dopamine mimetics. It is able to interact with dopamine-like receptors located in the pituitary gland. This leads to a significant suppression of the production of the hormone prolactin. In medicine, the drug is used in the treatment of a disease such as hyperprolactinemia. Cabergoline is also used actively in bodybuilding.

In addition, cabergoline may be effective against menstrual irregularities, galactorrhea, low sexual desire and impotence. It is also used to prevent inhibition of the breastfeeding process. In addition to its ability to interact with dopamine-like receptors, cabergoline is a weak alpha-1 and alpha-2 adrenergic receptor agonist.

The drug acts as a dopamine-like receptor agonist. The active substance is a derivative of ergoline, which makes it possible to have a strong hypoprolactinogenic effect. Cabergoline acts on dopamine receptors, which reduce the concentration of prolactin in the blood. The effectiveness of the drug is noticeable already three hours after application. When cabergoline is used by men, there is no effect on other hormones. The only side effect is lowering blood pressure.

Athletes taking anabolic steroids often experience symptoms of gynecomastia. This is a serious disease due to hormonal imbalance, it is expressed not only in the growth of the mammary glands, but also manifests itself in the presence of breastfeeding. In a man, a small amount of fluid can be released by squeezing the nipple. This symptom indicates hormonal disorders.

There is usually an imbalance between estrogen, prolactin and medication. When its symptoms appear, it is necessary to adjust the dosage of anabolic steroids, as well as to use cabergoline in case of an increase in the concentration of prolactin.

The use of the drug in doses exceeding the therapeutic dose may reduce the concentration of prolactin as well as achieve a strong dopaminergic effect. The level of prolactin begins to drop as early as three hours after use of the drug and is kept at the required level for one to four weeks.

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Effects of Cabergoline

Effects of Cabergoline

Positive properties of Cabergoline

The drug is a selective agonist of dopamine-like receptors and at the same time acts quite specifically. It should be noted its high similarity to D2 receptors, but the drug interacts weakly with adrenergic (alpha-1 and alpha-2) and serotonergic (5-HT1, 5-HT2) receptors.

For therapeutic purposes, this tool is used to treat hyperprolactinemia, hypersecretion of the hormone prolactin from the pituitary gland as well as in Parkinson’s disease. The drug has a great ability to inhibit the synthesis of prolactin, and it is for this reason that cabergoline is very popular in bodybuilding. At the same time, the drug interacts with D2 receptors. Dopamine thus becomes a negative feedback for the release of prolactin.

We have already said that an important feature of the drug is its inability to affect the synthesis of other hormonal substances synthesized by the cellular structures of the pituitary gland – corticotropin, somatotropin, luteinizing and thyroid stimulating hormones.

Prolactin is part of the same group of hormones as growth hormone. It is a single-peptide substance whose molecule contains 199 amines. Although slightly larger in size than growth hormone, prolactin is similar in many ways to somatotropin. But as soon as the conversation revolves around the structure of these substances, all similarities disappear immediately.

Prolactin is not able to exhibit anabolic properties, but is intended to stimulate lactation processes. This fact suggests that dostinex is very important for women because of its physiological properties. This is especially noticeable during pregnancy as it allows you to speed up the production of breast milk. The drug can also be used in the postpartum period with hypersynthesis of milk to inhibit this process.

At present, researchers do not know the therapeutic value of prolactin relative to the male body. It has been established that a high concentration of this hormonal drug can induce the development of impotence, infertility and gynecomastia. But disputes between scientists do not end with the last property of prolactin, and not everyone thinks it is possible.

Gynecomastia is quite rare in normal men, but not uncommon in AAS users. This is one of the reasons why cabergoline is such a hit in bodybuilding. Note that breastfeeding gynecomastia is accompanied by the release of a small amount of fluid when the nipple is compressed. This disease has the ability to accumulate and this fact is known by many athletes. At the first signs of developing gynecomastia, they make appropriate adjustments to their anabolic course.

Lactational gynecomastia is poorly understood and the cause of its development is thought to be an imbalance between prolactin, estrogens and androgens. In addition, the disease may be the result of a genetic predisposition. To avoid all these nuisances, it is necessary to use cabergoline in bodybuilding.

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Side effects of Cabergoline

In general, the drug is safe, but even when used, the body has its own reactions to the drug itself or its overdose. These may include nausea, vomiting, headache and decreased immunity. Any side effects only occur with uncontrolled use of the drug when you not only prescribe it yourself but also do not take a blood test for hormones, adjust the dosage and that you do not seek professional help. It is also important that the use of cabergoline in bodybuilding begins with an increase in prolactin, and not according to the schemes.

The basic rules for taking the drug are as follows:

  • before starting the course, undergo a hormone test;
  • if you already have high prolactin before the start of steroid use, as well as other hormonal abnormalities, for example with LH, FSH, it is worth waiting with the course of anabolic steroids, and you should be examined by a doctor;
  • Even if you have chosen a sparse dose on a steroid regimen, it is important to monitor the level of hormones in your blood throughout the period you are taking them;
  • with an increase in prolactin it is urgent to start taking cabergoline.

There are groups of people who should not use the remedy. If you are under 16, your body is sensitive to any of the ingredients of the drug and you suffer from chronic diseases, cabergoline in bodybuilding is contraindicated.

How to take cabergoline on the course of anabolics and PCT?

How to take cabergoline on the course of anabolics and PCT?

Cabergoline in sports should be used only on the basis of hormonal indicators from the bodybuilder, its dosage is chosen by a professional. But there are general guidelines.

In medical practice, the drug is used by men to suppress prolactin production in the amount of 0.5 grams per week. The dosage can be used at one time or divided into two or more doses. You can also increase the frequency of Dostinex need for better results by using 0.5 grams every three or four days.

The most common single dose is 0.25 mg. The drug is used once and the frequency of doses may vary. Depending on the case and the dynamics of the results, cabergoline is taken from once a week to once a month. In very rare cases, the frequency of administration reaches several times a week. There is no clear and common model. On average, it turns out that on a steroid course, cabergoline is taken in the amount of 0.25 mg twice a month.

Cabergoline in bodybuilding is used more often during anabolics with progestogen activity. These are drugs like nadrolone and trenbolone. As mentioned above, prolactin can be increased not only from these steroids but also from anabolics without pronounced progestin activity. The duration of cabergoline intake depends on the duration of the course of steroids, their type, and also whether or not there is control over the level of hormones during the course.

There are cases where the drug has been used by men to achieve multiple orgasms during sex. This fact can be explained by the high rate of dopamine synthesis during sex. After the body, there is a strong release of prolactin and all the accumulated dopamine is neutralized. This fact is related to the fact that after the body, men’s sexual arousal disappears quickly. If you block the production of prolactin using dostinex, more orgasms become a reality. Athletes do not use cabergoline.

Cabergoline is also taken on PCT in cases where prolactin, after use of steroids, continues to be produced in excess. In this situation, the drug will help restore the production of your own testosterone.